许多抗癌药被认为是致癌剂.应用某些药物或联合用药特别易引致第二种肿瘤的发生;诸如氮芥、长春新碱、甲基苄肼和强的松用于何杰金氏病;烷化剂长期用于骨髓瘤、卵巢癌、肺癌和非何杰金氏淋巴瘤等.本文作者研究了1958～1978年间经化疗后长期存活的绒毛膜上皮癌和恶性葡萄胎病人第二种肿瘤的发生率.在457例病人中,除2例外,全部病例均使用了 Many anticancer drugs are considered to be carcinogens. The use of certain drugs or combination drugs is particularly likely to cause the occurrence of a second tumor; for example, nitrogen mustard, vincristine, procarbazine and prednisone for Hodgkin’s disease The alkylating agents have long been used in myeloma, ovarian cancer, lung cancer and non-Hodgkin’s lymphoma. The authors studied the second-term survival of choriocarcinoma and malignant mole patients after chemotherapy in 1958-1978. Incidence of tumors. In 457 patients, all cases were used with 2 exceptions.