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阿糖腺苷(adenine arabinoside,Ara-A)是一种嘌呤类核苷,它在体内对一些DNA病毒具有抗病毒的作用.临床有报道应用Ara-A能抑制乙型肝炎病毒(HBV)DNA聚合酶(DNAp)的活性.强的松龙长期被用于治疗慢性肝炎,有些研究提示强的松龙可助长HBV复制;但也有人认为应用类固醇后骤停,可致HBV-DNAp的活性降低;还有报道癌肿化疗后,HBV标志物有所下降.鉴于上述报告,本文作者在慢性乙型肝炎病人中应用Ara-A、强的松龙骤停或二药联合治
Adenine arabinoside (Ara-A) is a purine nucleoside that acts as an antiviral agent against some DNA viruses in vivo.It has been reported in clinical practice that Ara-A can inhibit hepatitis B virus (HBV) DNA Polymerase (DNAp) activity. Prednisolone has long been used to treat chronic hepatitis. Some studies suggest that prednisolone can promote HBV replication. However, some people think that the use of post-steroid arrest can reduce the activity of HBV-DNAp ; There are reports of cancer chemotherapy, HBV markers decreased. In view of the above report, the author of chronic hepatitis B in patients with Ara-A, prednisolone or two drugs combined therapy