小儿重度有机磷中毒 ,按常规救治 ,清除毒物 ,应用阿托品及胆碱酯酶复能剂 ,在临床上仍存在着一定的问题 ,尤其是重度口服中毒者 ,抢救成活率低 ,死亡率仍在 6 0 %以上[1] 。我科采用早期置换新鲜全血[1,2 ] ,使体内胆碱酯酶活性迅速提高 ,成功地救治 1例重度有机磷中毒患儿 , Children with severe organophosphate poisoning, according to the conventional treatment, removal of poisons, the application of atropine and cholinesterase agents, there are still some clinical problems, especially severe oral poisoning, the survival rate of rescue is low, the mortality rate is still 6 0% or more [1]. Our department used early replacement of fresh whole blood [1,2], so that the rapid increase of cholinesterase activity in the body, the successful treatment and treatment of 1 case of severe organic phosphorus poisoning in children,