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目的:探讨植物毒素碘化油乳化的缓释作用,以及乳化前后对机体的急性毒性差别。材料与方法:将蓖麻蛋白水剂和碘化油蓖麻蛋白乳剂分别用不同剂量注入小鼠腹腔,观察即刻反应和死亡高峰期、以及大体尸检情况。结果:蓖麻蛋白水剂的 LD_(50)为12.78μg/kg,碘化油蓖麻蛋白乳剂的 LD_(50)为23.79μg/kg,两者 P<0.05,有明显差异。死亡高峰期后者比前者推迟2～3天。结论:蓖麻蛋白碘化油乳化后可以达到缓释,在不增加副作用的情况下,碘油乳化后用量可增加。
OBJECTIVE: To investigate the sustained release effect of phytotoxic emulsified iodinated oil and the acute toxicity to the body before and after emulsification. MATERIALS AND METHODS: The ricin and iodized oil castor oil emulsions were injected into the peritoneal cavity of mice at different doses to observe the immediate response and the peak of death, as well as the general autopsy situation. Results: The LD_ (50) of ricin aqueous solution was 12.78μg / kg, while the LD_ (50) of iodinated oil ricin emulsion was 23.79μg / kg, both P <0.05. The latter peak postponed than the former two to three days postponed. CONCLUSION: Ricin iodine oil can be slowly released after emulsification. Under the condition of no increase of side effects, the dosage of lipiodol can be increased after emulsification.