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HER-2(C-erbB2)的中文名称是人表皮生长因子受体-2,目前用于检测HER-2的主要方法两种:免疫组织化学法(IHC)用特异的抗体检测HER-2蛋白和荧光免疫杂交法(FISH)检测HER-2基因的扩增。一般情况下,所有乳腺癌的标本均进行IHC法检测HER-2,结果分为(-)、(+)、(++)、(+++)等几种情况,(-)和(+)通常定义为HER-2阴性,(+++)定义为HER-2阳性(过表达),而对于(++),
The Chinese name of HER-2 (C-erbB2) is human epidermal growth factor receptor-2. There are two main methods currently used to detect HER-2: immunohistochemistry (IHC) to detect HER-2 protein And fluorescence immunofluorescence (FISH) detection of HER-2 gene amplification. Under normal circumstances, all breast cancer specimens were detected by IHC HER-2, the results were divided into (-), (+), (++), (+++) and other cases, ) Is commonly defined as negative for HER-2, (+++) is defined as HER-2 positive (overexpression), whereas for (++),