论文部分内容阅读
目的:对复方黄芩喷雾剂进行药理试验研究,考察其对几种真菌抑制的作用,以及制剂对动物皮肤的过敏、急性毒性、刺激性的情况。方法:采用试管内药基法,进行真菌抑制试验;通过动物皮肤接触复方黄芩喷雾剂,观察动物皮肤有无过敏反应;通过动物完整皮肤及破损皮肤短时间接触复方黄芩喷雾剂有无急性毒性;观察动物完整皮肤及破损皮肤多次接触复方黄芩喷雾剂后有无局部刺激反应。结果:本品对试验的几种真菌均有抑制作用,对实验动物没有局部或全身过敏,也未见明显的急性毒性和刺激性。结论:复方黄芩喷雾剂对试验的几种真菌有很好的抑制作用,对实验动物没有明显的过敏,急性毒性和刺激性,为临床提供了有力的支持。
OBJECTIVE: To study the pharmacological effects of Scutellaria baicalensis Georgi Spray on the inhibition of several fungi, as well as the allergic, acute toxicity and irritation of animal skin. Methods: In vitro drug-based method was used to test the fungal inhibition. Animal skin was exposed to Compound Scutellariae Radix Scutellariae to observe the presence or absence of anaphylactic reaction in animal skin. Acute toxicity was given to Compound Scutellariae Spray through intact skin and broken skin of animals for a short time. Observed animal intact skin and damaged skin repeated exposure to compound skullcap spray with or without local irritation. Results: This product has inhibitory effect on several fungi tested, there is no local or systemic allergy to experimental animals, and no obvious acute toxicity and irritation. Conclusion: Scutellariae Radix Scutellariae spray has a good inhibitory effect on several fungi tested, no obvious allergy, acute toxicity and irritation to experimental animals, and provides strong support for clinical trials.