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目的探讨西沙比利对中、重型颅脑损伤病人胃排空的影响。方法选择GCS≤10分的20例颅脑损伤病人应用完全胃肠道营养,并随机分为二组,一组为西沙比利组,另一组为对照(生理盐水)组。测定两组病人血中的扑热息痛含量,并以此作为胃排空的指征。结果无论组间(西沙比利组和生理盐水对照组),还是组内的血浆浓度时间曲线下面积(AUC)、最大血药浓度(Cmax)、达到最大血药浓度时间(Tmax)均无显著性差异。结论本组结果提示西沙比利不能有效加强中、重型颅脑损伤病人胃排空。
Objective To investigate the effect of cisapride on gastric emptying in patients with severe traumatic brain injury. Methods Twenty patients with craniocerebral injury with GCS≤10 were enrolled in the study. Total gastrointestinal nutrition was randomly divided into two groups: one group is cisapride and the other is control group. The paracetamol content in the two groups of patients was determined and used as an indication of gastric emptying. Results There was no significant difference in the area under the curve of plasma concentrations (AUC), maximum plasma concentration (Cmax) and maximum plasma concentration (Tmax) between the two groups (cisapride and saline control group) Sex differences. Conclusions The results of this study suggest that cisapride can not effectively improve gastric emptying in patients with severe traumatic brain injury.