Background Eccrineangiomatoushamartoma (EAH) is a rare benign disease that comprises vascular and eccrine malformations. Pain is one of the most common symptoms and surgical resection is generally required.Objective To report a novel surgical technique that can alleviate severe pain caused by a large lesion in an EAH patient. Methods On magnetic resonance imaging (MRI), a subcutaneous abnormal signal was detected in the right hip and groin area of an 18-year-old male. The lesion was carefully elevated from the normal tissue above the plane of the deep fascia and was sutured in situ. Additionally, a small sample of the central lesion tissue was collected for histological examination. Results The visual analog scale score of pain decreased from 9 points to 2 points at 1week and to 0 points at 2 weeks after the surgery. The only complication observed was local numbness, which recovered spontaneously.No recurrence of pain was observed after 1 year of surgery. Histological ifndings demonstrated that the numbers of eccrine sweat glands and abnormal vessels decreased post-surgery. Conclusion The surgical procedure used in our case may represent a novel, easy, safe, and effective option for the treatment of a large, severely painful EAH.