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铅、汞、镉作为生物机体的有毒金属元素。现已证实哺乳动物的睾丸、附睾对镉的毒性作用很敏感、而镉与睾丸组织的肿瘤和不育症等疾患有密切关系。但铅和汞对雄性动物生殖功能的影响问题,意见尚未一致。本文用体外试验方法,观察了铅、汞和镉对睾丸组织匀浆脂质过氧化作用的影响,以期对铅、汞、镉的生殖毒性提供依据。1 材料与方法制备睾丸组织匀浆雄性Wistar-今道木鼠,体重200～250克。断头处死、放尽血液迅速取出睾丸、剥去包膜,称重。将睾丸剪碎加一定体积KCl-Tris
Lead, mercury, and cadmium are toxic metal elements of biological organisms. It has been confirmed that the testis and epididymides of mammals are sensitive to the toxic effects of cadmium, and that cadmium is closely related to the diseases of testicular tissue such as tumors and infertility. However, opinions on the effects of lead and mercury on the reproductive function of male animals have not been consistent. In this paper, the effects of lead, mercury, and cadmium on the lipid peroxidation of testicular tissue homogenate were observed using in vitro methods in order to provide evidence for the reproductive toxicity of lead, mercury, and cadmium. 1 Materials and Methods Preparation of Testicular Tissue Homogenate Male Wistar-Kowloon, weighing 200-250 g. The decapitation was performed and the blood was quickly removed from the testes, the capsules were peeled off and weighed. The testicles are cut and crushed to a certain volume of KCl-Tris