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为了探讨紫草辅助米非司酮抗早孕时对早孕妇女血中生殖激素的影响 ,88例早孕妇女随机分成服用米非司酮、紫草、米非司酮加紫草组和空白对照组 ,比较用药前后血人绒毛膜促性腺激素β亚单位 (β-h CG)、卵泡刺激素 ( F SH)、黄体生成素 ( L H)、雌二醇 ( E2 )、孕酮 ( P)和睾酮 ( T)的变化。结果 :单用米非司酮或紫草均对 β-h CG有一定的抑制作用 ,二者合用抑制作用更加明显 ;单用紫草对血中 FSH、 L H有较明显的抑制作用 ,对 E2 、P及 T无明显影响。认为紫草对绒毛功能有一定的影响 ,与米非司酮合用影响更明显 ;紫草对垂体生殖激素有明显的抑制作用。但是否与紫草能提高药物流产效果有关 ,尚需进一步研究。
In order to investigate the effect of comfrey adjuvant mifepristone on the blood reproductive hormones in early pregnant women during anti-first trimester pregnancy, 88 pregnant women were randomly divided into mifepristone, comfrey, mifepristone plus comfrey group and blank control group, The levels of blood β-hCG, F SH, LH, E2, P and testosterone were compared before and after treatment T) changes. Results: Both mifepristone and comfrey alone could inhibit β-h CG to a certain extent, and the combined effect was more obvious. The application of comfrey alone had a significant inhibitory effect on FSH and LH in blood, , P and T had no significant effect. It is concluded that Lithospermum has a certain influence on the function of villus and has a more obvious effect when combined with mifepristone. Lithospermum has a significant inhibitory effect on pituitary reproductive hormone. But whether Lithospermum can improve the effect of medical abortion, still need further study.