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目的检测鼻咽癌组织中Survivin的表达及肿瘤细胞凋亡情况。方法应用原位杂交和原位末端标记技术对64例鼻咽癌和30例慢性鼻咽炎鼻咽部组织中Survivin的表达和细胞凋亡进行检测,并分析两者之间的关系。结果鼻咽癌Survivin的阳性表达率为65.6%,慢性鼻咽炎鼻咽部组织阳性表达率为33.3%,差异有极度统计学意义(P<0.01);在Survivin阳性表达和阴性表达的组织中,细胞凋亡指数分别是(0.63±0.36)和(1.58±0.44),Survivin阳性表达者明显低于Survivin阴性表达者;差异有统计学意义(P<0.05)。慢性鼻咽炎鼻咽部组织中细胞凋亡指数为1.32±0.36,与NPC Survivin阳性表达者比较差异有统计学意义(P<0.05)。结论在鼻咽癌的发生发展过程中Survivin表达引起的凋亡抑制可能有一定的作用。
Objective To detect the expression of Survivin and the apoptosis of tumor cells in nasopharyngeal carcinoma. Methods The expression of Survivin in 64 cases of nasopharyngeal carcinoma and 30 cases of nasopharyngeal nasopharyngeal tissues were detected by in situ hybridization and in situ end-labeling. The relationship between them was analyzed. Results The positive rate of Survivin in nasopharyngeal carcinoma was 65.6%, the positive rate of nasopharyngeal tissues in chronic nasopharyngitis was 33.3%, the difference was statistically significant (P <0.01). Among the Survivin positive and negative tissues, The apoptotic index was (0.63 ± 0.36) and (1.58 ± 0.44), respectively. The positive expression of Survivin was significantly lower than that of Survivin. The difference was statistically significant (P <0.05). The apoptotic index in nasopharyngeal tissues of chronic nasopharyngitis was 1.32 ± 0.36, which was significantly different from that of NPC Survivin positive (P <0.05). Conclusion The inhibition of apoptosis induced by Survivin may play a role in the development of nasopharyngeal carcinoma.