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目的 观察七叶皂苷钠治疗糖尿病周围神经病变的疗效。方法 采用七叶皂苷钠治疗糖尿病周围神经病变 10 1例 ,同时与复方丹参注射液治疗的 6 8例进行对照。结果 治疗组总有效率 88 11% ,对照组总有效率 5 5 88% (P <0 0 5 )。治疗组治疗后空腹血糖略有下降 (P >0 0 5 ) ,餐后 2h血糖、血脂、肾功能、血压、HbA1c无明显变化。糖尿病周围神经病变病程 <1年者有效率 10 0 % ,病程 1～ 3年有效率 92 5 9% ,病程 >3年有效率 71 83%。结论 七叶皂苷钠治疗糖尿病周围神经病变有较好的疗效 ,糖尿病周围神经病变病程越短疗效越好。
Objective To observe the therapeutic effect of sodium aescinate on diabetic peripheral neuropathy. Methods 10 cases of diabetic peripheral neuropathy were treated with sodium aescinate, while 68 cases were treated with compound Salvia miltiorrhiza injection. Results The total effective rate was 88.11% in the treatment group and 55.8% (P <0.05) in the control group. After treatment, the fasting blood glucose of the treatment group decreased slightly (P> 0.05), and there was no significant change of blood glucose, blood lipid, renal function, blood pressure and HbA1c 2h after meal. The course of diabetic peripheral neuropathy <1 year was 100%, the course of disease was 1-3 years, the effective rate was 92 59%, and the course of disease> 3 years was 71 83%. Conclusion Sodium aescinate treatment of diabetic peripheral neuropathy have a good effect, the shorter duration of diabetic peripheral neuropathy, the better the effect.