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作者报告了两例皮肤原位癌的附件化生。一例为粘蛋白化生,另一例为皮脂腺化生。这些变化提示:肿瘤表皮角朊细胞分化可能有一谱状模型,有助于了解某些皮肤肿瘤的组织发生。例一,54岁男性银屑病患者,近年来阴茎上长一“表皮样癌”。组织学检查显示表皮全层角朊细胞出现异形和大量丝状分裂,常为异形分裂象,真皮内有淋巴细胞、浆细胞组成的慢性炎性浸润。部分表皮细胞有透明含粘蛋白细胞浆,呈灶状分布,有的类似印戒细胞,有的象长的杯状细胞,无异形。胭脂红染色证实细胞内粘蛋白阳性,淀粉酶消化后,过
The authors reported two cases of accessory metaplasia of skin in situ carcinoma. One case is mucinous and the other is sebaceous gland metaplasia. These changes suggest that there may be a spectral pattern in the differentiation of neoplastic epidermal keratinocytes, which helps to understand the occurrence of certain skin tumours. For example, a 54-year-old male patient with psoriasis had a “epidermoid carcinoma” on his penis in recent years. Histological examination showed that the epidermis full-thickness keratinocytes appeared abnormal and a large number of filiform divisions, often heteromorphic, with chronic inflammatory infiltration of lymphocytes and plasma cells in the dermis. Some of the epidermal cells have clear mucinous cytoplasm, which is focally distributed, some resembling signet ring cells, and some resembling long goblet cells without abnormal shape. Carmine stain confirmed intracellular mucin positive, after amylase digestion, over