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目的 :探讨高压氧联合川芎嗪注射液治疗急性一氧化碳中毒的临床疗效。方法 :将88例急性一氧化碳中毒分为研究组(n=44)和对照组(n=44)。对照组采用高压氧治疗。研究组采用高压氧联合川芎嗪注射液治疗。对比两组治疗前后血气指标、炎症因子指标变化。对比两组苏醒时间、住院时间、迟发性脑病的发生率。结果 :观察组总有效率(93.18%)显著高于对照组(75.00%),差异有统计学意义;两组治疗后血氧分压(Pa O2)显著升高,血二氧化碳分压(Pa CO2)、肿瘤坏死因子a(TNF-α)、白介素6(IL-6)显著降低;治疗24h后,研究组Pa O2显著高于对照组,Pa CO2、TNF-α、IL-6显著低于对照组,差异有统计学意义;研究组苏醒时间、住院时间、迟发性脑病的发生率显著低于对照组,差异有统计学意义。结论 :高压氧联合川芎嗪注射液能显著改善急性一氧化碳中毒的症状,减轻炎症反应,降低迟发性脑病的发生。
Objective: To investigate the clinical efficacy of hyperbaric oxygen combined with ligustrazine injection in the treatment of acute carbon monoxide poisoning. Methods: 88 cases of acute carbon monoxide poisoning were divided into study group (n = 44) and control group (n = 44). The control group was treated with hyperbaric oxygen. The study group was treated with hyperbaric oxygen combined with ligustrazine injection. Before and after treatment, blood gas indexes and inflammatory cytokines were compared. Compare the recovery time of two groups, hospitalization time, the incidence of delayed encephalopathy. Results: The total effective rate (93.18%) in the observation group was significantly higher than that in the control group (75.00%), the difference was statistically significant. After treatment, the PaO2 was significantly increased, Pa CO2 ), TNF-α and IL-6 were significantly decreased. PaO2 in study group was significantly higher than that in control group after 24-hour treatment, PaCO2, TNF-α and IL-6 were significantly lower than those in control group Group, the difference was statistically significant; the study group wake time, hospital stay, delayed encephalopathy incidence was significantly lower than the control group, the difference was statistically significant. Conclusion: Hyperbaric oxygen combined with ligustrazine injection can significantly improve the symptoms of acute carbon monoxide poisoning, reduce inflammation and reduce the incidence of delayed encephalopathy.