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目的:探讨IgA肾病(IgAN)超微结构病变的病理学意义及在本病演化进展中的作用。方法:对122例肾活检组织,进行系统的超微结构观察,以半定量的方法对各项超微结构病变进行分级,并和肾小球损伤程度及免疫学类型相对照,进行统计学处理。结果:肾小球系膜旁区大量沉着、基膜内皮下或上皮下沉着、系膜基质溶解、旁区病变、基膜异常以及系膜细胞插入,都是肾小球病变进展过程中较早期的超微病变,其出现频率均和肾小球损伤程度呈正相关,尤其是系膜旁区大量沉着、上皮下、内皮下沉着物及系膜溶解和肾小球损伤程度的关系更为密切。结论:IgAN时免疫复合物在肾小球内沉着的数量及部位对病变进展有很大影响。
Objective: To investigate the pathological significance of IgA nephropathy and its role in the evolution of this disease. Methods: 122 cases of renal biopsy tissues were observed ultrastructurally, and the ultrastructural lesions were graded by semi-quantitative method, and compared with the degree of glomerular injury and immunological types, statistical analysis . Results: A large number of glomerular mesangial area was serous, subepithelial or subepithelial submucous, mesangial matrix lysis, paracancerous lesions, abnormalities of basilar membrane and mesangial cells were the early stage of progression of glomerular lesions The frequency of occurrence was positively correlated with the degree of glomerular injury. In particular, there was a significant correlation between the mesothelial cell mass, the subepithelial and endothelium deposition, mesangial lysis and glomerular damage. Conclusion: The number and location of IgAN immune complexes in the glomeruli have a great impact on the progression of the disease.