人类细胞具有一系列DNA修复系统,以防御体内和体外因素引起的不同类型的DNA损伤,保持基因组的完整性。研究表明DNA修复能力低可能与个体肿瘤易感性密切相关,然而在肿瘤的治疗过程中,DNA损伤修复能力的增加却阻碍了疗效的发挥。肿瘤细胞DNA修复能力与化疗敏感性密切相关。近来许 Human cells have a series of DNA repair systems to protect against different types of DNA damage caused by in vivo and in vitro factors, maintaining the integrity of the genome. Studies have shown that low DNA repair capacity may be closely related to individual tumor susceptibility. However, in the course of tumor treatment, the increase in the ability of DNA damage repair has hindered the exertion of efficacy. The DNA repair ability of tumor cells is closely related to the sensitivity of chemotherapy. Recent promises