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采用放射免疫分析法分别测定了12例全身性惊厥性癫痫持续状态患儿(GCSE)和8例非癫痫持续状态的癫痫患儿(EP)在惊厥发作后24小时内血浆中β-EP的含量。结果显示血浆中β-EP水平,GCSE组、EP组均高于对照组(P<0.05,P<0.001);EP组高于GCSE组(P<0.001);GCSE组伴急性神经系统损伤与不伴急性神经系统损伤、预后良好者与预后差者无显著性差异(P=0.7370,P=0.2530)。提示血浆中的β-EP在癫痫持续状态和癫痫发作后水平增高,在惊厥发作后24小时内参与中可能作为内源性的抗痫物质存在。其含量水平不能判断脑损伤的程度和提示预后。
Radioimmunoassay was used to determine the plasma levels of β-EP in 12 children with seizure-induced seizure (GCSE) and 8 children with epilepsy without seizure (EP) within 24 hours after seizure onset . The levels of β-EP in plasma were higher in GCSE group and EP group than those in control group (P <0.05, P <0.001), those in EP group were higher than those in GCSE group (P <0.001) Associated with acute neurological injury, there was no significant difference between those with good prognosis and those with poor prognosis (P = 0.7370, P = 0.2530). Suggesting that β-EP in plasma is elevated in status epilepticus and after seizures and may be present as an endogenous anti-epileptic substance within 24 hours of seizure onset. The level of its content can not determine the extent of brain damage and prompt prognosis.