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目的 观察复方贞杞口服液对化疗药物丝裂霉素(MMC)、环磷酰胺(CTX)抗肿瘤活性及某些衰老指标的影响.方法采用动物移植瘤S_180、H_22模型,对复方杞口服液与MMC、CTX合用的抗肿瘤活性及免疫功能进行检测.采用18月龄老年和1月龄青年鼠模型,用MDA-TBA比色法测MDA含量,用光还原NBT法测SOD活性,用分光光度法测MAO—B活性.结果复方贞杞口服液明显增加MMC、CTX抗肿瘤活性,对其所引起免疫抑制性有明显保护作用;并能明显降低小鼠脏器组织中MDA含量,抑制MAO-B活性,增强SOD活性.结论 复方贞杞口服液能增强机体的免疫功能,对老化代谢产物及相关酶活性的影响,可能是对化疗药物增效解毒及抗衰老作用的机制.
Objective To observe the effects of compound Zhenqi Oral Liquid on the anti-tumor activity of mitoxantrone (MMC) and cyclophosphamide (CTX) and some aging indexes of the chemotherapeutic drugs.Methods The animal model of S_180 and H_22 And anti-tumor activity and immune function in combination with MMC and CTX.The content of MDA was detected by MDA-TBA colorimetric method and SOD activity was measured by photoreduction NBT method using 18-month-old and 1-month- The activity of MAO-B was measured by spectrophotometry.Results The compound Zhenzheng oral solution obviously increased the antitumor activity of MMC and CTX, and obviously inhibited the immunosuppressive activity induced by MMC.It also significantly reduced the content of MDA in the tissues of mice and inhibited the activity of MAO B activity and SOD activity.Conclusion Compound Zhenqi Oral Liquid can enhance the immune function of the body, the effects of aging metabolites and related enzymes may be the mechanism of synergistic detoxification and anti-aging effects of chemotherapy drugs.