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目的:探讨fractalkine(FKN)在OLP中的表达及意义。方法:采用免疫组织化学方法,检测FKN在34例OLP中表达情况,分析FKN阳性着色与OLP临床类型、年龄、性别及发病部位的关系。结果:FKN在OLP角质形成细胞中高表达,FKN阳性细胞率为(45.4±16.2)%;在糜烂-萎缩型OLP中,角质形成细胞FKN染色分值(2.8±0.7)较斑纹型OLP染色分值(1.9±0.8)高,有显著性差异(P<0.05)。OLP黏膜下层血管内皮细胞也发现FKN高表达。结论:FKN在角质形成细胞及血管内皮细胞中的高表达,可与T淋巴细胞相互作用,可能通过一种旁分泌反馈机制参与OLP发病机制,加重炎症反应。
Objective: To investigate the expression and significance of fractalkine (FKN) in OLP. Methods: Immunohistochemical method was used to detect the expression of FKN in 34 cases of OLP. The relationship between FKN positive staining and the clinical type, age, sex and incidence of OLP was analyzed. Results: FKN was highly expressed in keratinocytes of OLP, the positive rate of FKN was (45.4 ± 16.2)%. In erosive-atrophic OLP, FKN staining of keratinocytes was (2.8 ± 0.7) (1.9 ± 0.8), there was a significant difference (P <0.05). OLP submucosal vascular endothelial cells also found that FKN high expression. CONCLUSION: FKN is highly expressed in keratinocytes and vascular endothelial cells and interacts with T lymphocytes. It may participate in the pathogenesis of OLP and aggravate inflammatory reaction through a paracrine feedback mechanism.