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米力农(milrinone)是一种磷酸二酯酶抑制剂,通过提高细胞内cAMP水平增强心肌收缩力,但是这类正性肌力药物对慢性心衰患者存活率的长期影响还未确定。将有严重慢性心衰(NYHA Ⅲ～Ⅳ级)和重度左室功能不全的1.088例患者随机分为治疗组(561例)和安慰剂组(527例)。治疗
Milrinone is a phosphodiesterase inhibitor that increases myocardial contractility by increasing intracellular cAMP levels, but the long-term impact of such inotropic agents on survival in patients with chronic heart failure has not been established. A total of 1.088 patients with severe chronic heart failure (NYHA III-IV) and severe left ventricular dysfunction were randomized into treatment (561) and placebo (527) patients. treatment