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胰腺癌目前占中国癌症死因第6位,在实体肿瘤中预后最差,5年生存率低于5%~([1-3])。由于胰腺癌发病隐匿,80%的患者就诊时已处于中晚期,大部分患者已经丧失了手术治疗的机会,且胰腺癌对放化疗也不敏感~([4])。因此临床医生一直致力于研究胰腺癌的发病机制以及寻找抗肿瘤的靶向位点,希望能早期发现和早期治疗胰腺癌。脂联素是脂肪细胞分泌的一种多效性脂肪因子,具有抗氧化、抗脂毒性、抗炎、增强胰岛素敏感性等作用~([5])。高浓度的脂
Pancreatic cancer currently accounts for the sixth leading cause of cancer death in China, with the poorest prognosis in solid tumors and a 5-year survival of less than 5% (1-3). Since the incidence of pancreatic cancer is insidious, 80% of patients are already in advanced stages of treatment. Most of the patients have lost the chance of surgical treatment, and pancreatic cancer is not sensitive to radiotherapy and chemotherapy (4). Therefore, clinicians have been committed to studying the pathogenesis of pancreatic cancer and looking for anti-tumor target sites, hoping to early detection and early treatment of pancreatic cancer. Adiponectin is a pleiotropic adipokine that is secreted by adipocytes and has the effects of anti-oxidation, anti-lipotoxicity, anti-inflammatory and insulin sensitivity. (5). High concentrations of fat