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含异烟肼(H)而不含利福平(R)方案引起肝炎者很少见(1.3%),但 HR 方案则相对多见(8～10%),而在 H 慢乙酰化代谢者较快代谢者发生率更高(11%:1%)。在体内部分 H 可由直接代谢途径被 H 水解酶水解形成异烟酸(INA)及胼;前者经结合成为异烟甘氨酸 INAG),另一部分由间接代谢途径先转变成乙酰异烟肼(AcINH),再经水解而成为 INA 及单乙酰肼(MAH)(见图)。慢乙酰化者较快乙酰化者更多的H 通过直接代谢途径产生肼,动物实验已知肼对肝脏
Hives with isoniazid (H) but not rifampicin (R) regimens are rare in patients with hepatitis (1.3%), but HR regimens are relatively common (8-10%), whereas those with slow acetylation A higher incidence of faster metabolizers (11%: 1%). In the body part of the H by the direct metabolic pathway is hydrolyzed by H hydrolase formation isonicotinic acid (INA) and the corpus; the former is bound to become isoniazid INAG), the other part by the indirect metabolic pathway first converted to acetyl isoniazid (AcINH) It is hydrolyzed into INA and monoacetylhydrazide (MAH) (see photo). Slower acetylator faster acetylator H more direct metabolic pathway to generate hydrazine, animal experiments known hydrazine on the liver