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为研究中药附子强心活性的物质基础,对其化学成分进行了研究。采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、MCI、ODS等柱色谱及制备液相色谱等手段从附子90%乙醇提取物中分离得到10个化合物,根据化合物的理化性质和波谱数据鉴定了其结构,分别为5-羟基-2-苯甲酰胺-苯甲酸甲酯(1)、和厚朴酚(2)、松脂醇(3)、水杨酸(4)、对羟基桂皮酸(5)、松果灵(6)、多根乌头碱(7)、新乌头碱(8)、次乌头碱(9)和苯甲酰次乌头碱(10)。化合物1为一个新的化合物,命名为附子酰胺(aconitamide),并通过核磁、质谱、紫外、红外及单晶衍射数据确定了其结构。化合物2~5为首次从附子中分离得到。
In order to study the material basis of aconite cardiac activity, the chemical constituents were studied. Ten compounds were isolated from 90% ethanol extract of Aconite using column chromatography on silica gel, Sephadex LH-20 column chromatography, MCI, ODS column chromatography and preparative liquid chromatography. The compounds were identified by physicochemical properties and spectral data The structures of the compounds were identified as 5-hydroxy-2-benzamide-methyl benzoate (1), honokiol (2), pinoresinol (3), salicylic acid 5), pinealin (6), aconitine (7), mesaconitine (8), hypaconitine (9) and benzoyl hypaconitine (10). Compound 1 is a new compound named aconitamide and its structure was confirmed by NMR, MS, UV, IR and single crystal diffraction data. Compounds 2 ~ 5 were isolated from the aconite for the first time.