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多巴胺激动剂对男人、妇女及动物的促性腺激素的分泌产生易变的影响,该反应的易变性可能反映着以下几方面的差异:所研究的生物胺,给药途径及持续时间,种属间差异以及受试者内在性激素环境的不同。多巴胺不能通过血脑屏障,因此它对促性腺激素分泌的影响必定作用于垂体、正中隆起或二者。作者研究了五例自然绝经的妇女,以期阐明多巴胺调节促性腺激素分泌的作用部位以及多巴胺是否影响由促性腺激素释放激素(GnRH)刺激的促性腺
Dopamine agonists have a variable effect on the secretion of gonadotropins in men, women and animals. The variability in this reaction may reflect differences in the biogenic amines studied, the route and duration of administration, the species The difference between the subjects and the sex hormone environment. Dopamine does not cross the blood-brain barrier, so its effect on gonadotropin secretion must act on the pituitary gland, the median bulge, or both. The authors studied five women with natural menopause to elucidate the site of action where dopamine regulates gonadotropin secretion and whether dopamine affects gonadotropins stimulated by gonadotropin-releasing hormone (GnRH)