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目的：探讨低剂量辐射（LDR）与环磷酰胺（CP）伍用对肿瘤生长的影响。方法：采用C57BL／6J，小鼠右后肢腓肠肌内接种Lewis肺癌细胞做为肿瘤动物模型。在肿瘤直径达7mm时，给予75mGyX射线全身照射和100mg／kgCP腹腔注射化疗，用游标卡尺隔日测量肿瘤直径，建立肿瘤生长曲线，同时检测了不同治疗措施后小鼠脾脏自然杀伤细胞（NK）、淋巴因子激活的杀伤细胞（LAK）、特异性细胞毒性T细胞（CTL）的杀伤活性。结果：同单纯CP化疗组相比，LDR与CP伍用组的肿瘤直径在治疗后不同时间均明显缩小（P＜0．05～0．01），肿瘤生长速率明显降低；LDR和CP伍用组小鼠的NK、LAK、特异性CTL杀伤活性较单纯CP化疗组明显提高（P＜0．05～0．01）。结论：LDR可通过减轻CP所致的免疫抑制副作用提高机体免疫系统的功能并增强CP的抑瘤作用。
Objective: To investigate the effects of low dose radiation (LDR) and cyclophosphamide (CP) on tumor growth. METHODS: C57BL/6J mice were used to inoculate Lewis lung cancer cells in the right hind limbs with gastrocnemius as a tumor animal model. When the tumor diameter reached 7mm, 75mGy X-ray whole body irradiation and 100mg/kg CP intraperitoneal injection chemotherapy were used. The tumor diameter was measured every day on a vernier caliper, and the tumor growth curve was established. At the same time, spleen natural killer cells (NK) and lymph were detected after different treatment measures. The killing activity of factor-activated killer cells (LAK), specific cytotoxic T cells (CTL). RESULTS: Compared with CP alone group, tumor diameters in LDR and CP groups were significantly reduced at different time points after treatment (P<0.05-0.01). Tumor growth rate was significantly reduced; LDR and CP were used The killing activity of NK, LAK and specific CTL in the mice was significantly higher than that of the simple chemotherapy group (P<0.05-0.01). Conclusion: LDR can improve the function of the immune system and enhance the anti-tumor effect of CP by alleviating the immunosuppressive side effects caused by CP.