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目的探讨肾移植受者与正常人群骨密度(BMD)的差异。方法选取肾移植受肾者53例为移植组(男23例,女30例),正常体检人群115例为对照组(男64例,女51例)。以双能X线吸收法测定腰椎、左股骨颈和全髋BMD,比较不同性别移植组和对照组BMD和骨质疏松发生率。结果男性移植组仅左股骨颈BMD明显低于同性别对照组(P<0.05),骨量减少和骨质疏松的总发生率分别为47.8%和35.9%,两组差异无统计学意义(P>0.05);女性移植组L1、左股骨颈和全髋BMD均明显低于对照组(P<0.05),骨量减少和骨质疏松的总发生率分别为66.7%和35.3%,移植组明显高于对照组(P<0.01)。结论肾移植受者BMD降低,且女性组骨量减少以及骨量减少和骨质疏松发生率高。
Objective To investigate the differences of bone mineral density (BMD) between renal transplant recipients and normal subjects. Methods Fifty-three renal transplant recipients were selected as the transplantation group (23 males and 30 females). 115 normal controls were selected as the control group (64 males and 51 females). The lumbar spine, left femoral neck and total hip BMD were measured by dual-energy X-ray absorptiometry. The incidences of BMD and osteoporosis were compared between different gender transplantation groups and control group. Results Only the left femoral neck BMD was significantly lower in the male transplanted group than in the same sex group (P <0.05). The overall incidence of osteopenia and osteoporosis were 47.8% and 35.9% respectively, with no significant difference between the two groups (P > 0.05). The BMD of L1, left femoral neck and total hip in female transplantation group were significantly lower than those in control group (P <0.05). The total incidence of osteopenia and osteoporosis were 66.7% and 35.3% Higher than the control group (P <0.01). Conclusions BMD of renal transplant recipients is decreased, and there is a high incidence of osteopenia and osteopenia and osteoporosis in females.