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目的探讨PINCH蛋白在非小细胞肺癌(NSCLC)中的表达及其与淋巴结转移和患者预后之间的关系。方法应用免疫组化EnVision法检测185例NSCLC及癌旁组织中PINCH蛋白的表达,分析其表达与患者术后淋巴结转移及预后之间的关系。结果 NSCLC组织中PINCH阳性表达率明显高于癌旁组织(P<0.01)。PINCH在NSCLC组织中的表达与淋巴结转移密切相关(P<0.01)。PINCH阳性表达组术后5年生存率为20.5%(16/78),而PINCH阴性表达组5年生存率为52.3%(56/107),两组间比较差异有统计学意义(P<0.05)。Cox回归多因素分析表明PINCH表达是影响NSCLC患者预后的独立预后因素(P<0.05)。结论 PINCH蛋白的表达可能在NSCLC发生淋巴结转移过程中发挥重要作用;检测其表达状态将可能有助于临床医生预测NSCLC患者的预后,并为NSCLC的分子靶向治疗提供新的靶点和思路。
Objective To investigate the expression of PINCH protein in non-small cell lung cancer (NSCLC) and its relationship with lymph node metastasis and prognosis. Methods The immunohistochemical EnVision method was used to detect the expression of PINCH protein in 185 cases of NSCLC and its adjacent tissues. The relationship between the expression of PINCH protein and the postoperative lymph node metastasis and prognosis was analyzed. Results The positive rate of PINCH in NSCLC tissues was significantly higher than that in adjacent non-cancerous tissues (P <0.01). The expression of PINCH in NSCLC was closely related to lymph node metastasis (P <0.01). The 5-year survival rate of PINCH-positive group was 20.5% (16/78), while that of PINCH-negative group was 52.3% (56/107), with significant difference between the two groups (P <0.05 ). Cox regression multivariate analysis showed that PINCH expression was an independent prognostic factor in patients with NSCLC (P <0.05). Conclusions The expression of PINCH protein may play an important role in the process of lymph node metastasis in NSCLC. Detecting its expression status may help clinicians predict the prognosis of patients with NSCLC, and provide new targets and ideas for the molecular targeted therapy of NSCLC.