论文部分内容阅读
目的:观察糖皮质激素治疗SARS患者出现的不良反应。方法:将98例SARS患者分为激素治疗组和对照组,激素治疗组57例,对照组41例。激素治疗组按照用药剂量分为<160mg·d-1(16例)、≥160,<320mg·d-1(35例)、≥320mg·d-1(6例)三组;按照用药疗程分为<20d(19例)、≥20d(38例)两组,并分析比较激素治疗组和对照组产生的不良反应。结果:激素组与对照组比较,发生低钾血症分别为43.9%和26.8%,血糖升高分别为45.6%和22%,继发细菌感染分别为31.6%和14.6%,减量过程中体温再次升高分别为38.6%和17.1%,胸片示炎症加重分别为21.1%和7.3%。激素组不良反应的发生率有随剂量、疗程的增加而增加的趋势。结论:激素治疗SARS患者有引起低钾血症、血糖升高、继发细菌感染的可能,激素减量过程中可出现病情反复。
Objective: To observe the adverse reactions of glucocorticoid in patients with SARS. Methods: 98 cases of SARS patients were divided into hormone therapy group and control group, hormone treatment group 57 cases, control group 41 cases. The hormone therapy group was divided into three groups according to the dosage: <160mg · d-1 (16 cases), ≥160, <320mg · d-1 (35 cases), and 320mg · d-1 (6 cases) For <20d (19 cases), ≥20d (38 cases) two groups, and analysis of hormone therapy group and control group of adverse reactions. Results: Compared with the control group, Hypokalemia was 43.9% and 26.8% in the hormone group and 45.6% and 22% in the hyperglycemia respectively. The secondary bacterial infections were 31.6% and 14.6% Again increased 38.6% and 17.1%, chest X-ray showed inflammatory exacerbations were 21.1% and 7.3%. The incidence of adverse reactions in hormone group increased with dose and course of treatment. Conclusion: Hormonal treatment of SARS patients may cause hypokalemia, elevated blood sugar, secondary bacterial infection may occur, the process of hormone reduction may occur repeatedly.