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目的：评价吸入一氧化氮（ＮＯ）对烟雾吸入性损伤犬肺功能的改善效果，并验证其作用机制。方法：２１只犬随机分为３组，烟雾吸入后的对照组（８只）给予单纯吸氧（ＦｉＯ２０．４５）；治疗组（９只）吸氧（ＦｉＯ２０．４５）＋０．００４５％ＮＯ，连续监测１２小时血气变化；正常组（４只）不致伤，用于建立组织学对照。数据行多个样本均数间方差分析。结果：治疗组肺氧合功能明显改善（Ｐ均＜０．０５），肺通气功能也明显改善（Ｐ均＜０．０５）；动脉血和肺组织环磷酸鸟苷（ｃＧＭＰ）明显升高（Ｐ均＜０．０１）。结论：吸入ＮＯ能明显改善肺功能，其作用机制为提高平滑肌细胞内ｃＧＭＰ水平。推荐临床应用吸入ＮＯ作为吸入性损伤的综合治疗方法。
Objective: To evaluate the effect of inhaled nitric oxide (NO) on the lung function of dogs with smoke inhalation injury and to verify the mechanism of action. Methods: Twenty-one dogs were randomly divided into three groups: FiO 20.45 (n = 8) and FiO 20.45 + 0.0045% NO (n = Continuous monitoring of 12-hour blood gas changes; normal group (4) not injury, for the establishment of histological control. Analysis of variance between multiple samples in data rows. Results: The pulmonary oxygenation function of the treatment group was significantly improved (P <0.05) and the pulmonary ventilation function was also significantly improved (P <0.05). The cGMP of the arterial blood and lung tissue was significantly increased P <0.01). Conclusion: NO inhalation can significantly improve lung function, its mechanism of action is to increase the level of cGMP in smooth muscle cells. Recommended clinical application of inhaled NO as a comprehensive treatment of inhalation injury.