长时程增强(LTP)是活性依赖的、在突触强度上的持续性增强,是研究海马学习记忆的经典模型。海马是完成学习、记忆活动的关键结构,LTP是海马增强突触传递效应的表现,是海马参与学习记忆过程的重要机制之一。在CA3~CA1区的神经突触,根据LTP持久性、持续机制、Ca2+离子信号通路,表达位点和电生理特性,可鉴定出3种不同形式的LTP(LTP1、LTP2和LTP3)。本实验室的前期研究发现,LTP2和LTP3涉及建立在翻译 Long-term potentiation (LTP) is activity-dependent, and its sustained increase in synaptic intensity is a classic model for learning and memory in the hippocampus. The hippocampus is the key structure to complete learning and memory activities. LTP is one of the important mechanisms involved in the learning and memory of the hippocampus in enhancing the synaptic transmission. Three different forms of LTP (LTP1, LTP2 and LTP3) were identified in CA3-CA1 neuronal synapses based on LTP persistence, persistence, Ca 2+ ion signaling, expression sites and electrophysiological properties. Previous studies in our laboratory found that LTP2 and LTP3 are involved in translation