Artificial nanorobot is a type of robots designed for executing complex tasks at nanoscale.The nanorobot system is typically consisted of four systems,including logic control,driving,sensing and functioning.Considering the subtle structure and complex functionality of nanorobot,the manufacture of nanorobots requires designable,controllable and multi-functional nanomaterials.Here,we propose that nanozyme is a promising candidate for fabricating nanorobots due to its unique properties,including flexible designs,controllable enzyme-like activities,and nano-sized physicochemical charac-ters.Nanozymes may participate in one system or even combine several systems of nanorobots.In this review,we summarize the advances on nanozyme-based systems for fabricating nanorobots,and prospect the future directions of nanozyme for constructing nanorobots.We hope that the unique properties of nanozymes will provide novel ideas for designing and fabricating nanorobotics.