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Foxp3~+调节性T细胞(Foxp3~+Treg)是一类能抑制免疫系统攻击机体自身组织的一类CD4~+T细胞亚群,其关键性表型特征在于表达Forkhead家族转录因子Foxp3。Foxp3在CD4~+调节性T细胞的分化、发育和功能稳定的过程中发挥着重要功能。Foxp3蛋白水平变化导致的调节性T细胞功能稳定性改变与人类多种重大免疫相关疾病如感染性疾病、自身免疫病、过敏性疾病、肿瘤发生与转移、移植排斥等密切相关。研究Foxp3+调节性T细胞分化发育和功能稳定性的分子机制,将为相关免疫疾病治疗提供新思路新靶点。
Foxp3 ~ + regulatory T cells (Foxp3 ~ + Tregs) are a class of CD4 ~ + T cell subsets that suppress the immune system from attacking the body’s own tissues, with a key phenotype characterized by the expression of the Forkhead family transcription factor Foxp3. Foxp3 plays an important role in the differentiation, development and stable function of CD4 ~ + regulatory T cells. The change of regulatory T cell function stability caused by the change of Foxp3 protein levels is closely related to many major immune-related diseases in humans, such as infectious diseases, autoimmune diseases, allergic diseases, tumorigenesis and metastasis, and transplant rejection. Studying the molecular mechanism of Foxp3 + regulatory T cell differentiation and functional stability will provide new ideas for the treatment of related immune diseases.