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利用伪三元相图,得到空白微乳的优化处方为Cremophor EL-中链甘油三酸酯-聚乙二醇400-注射用水(3.0:1.5:3.0:12.5,w/w)。在此基础上制备的o/w型萘普生微乳外观澄清,平均粒径为(52.5±3 2)nm,载药量为1.02%。进一步考察了萘普生微乳对小鼠的抗炎镇痛效果及其连续给药后对大鼠胃黏膜组织形态学的改变。结果表明,萘普生微乳中(60mg/kg)、高(120mg/kg)剂量组与阳性对照(阿司匹林肠溶片,100mg/kg)组和荼普生片剂(120mg/kg)组相比,具有相近或更强的抗炎镇痛作用,且微乳能减轻萘普生对大鼠胃黏膜的损伤作用。
Using pseudo-ternary phase diagram, the optimal formulation of blank microemulsion was Cremophor EL-medium chain triglyceride-polyethylene glycol 400-water for injection (3.0: 1.5: 3.0: 12.5, w / w). On this basis, the o / w Naproxen microemulsion has a clear appearance with an average particle diameter of (52.5 ± 3.2) nm and a drug loading of 1.02%. Further study naproxen microemulsion anti-inflammatory analgesic effect in mice and its continuous administration of gastric mucosal histomorphology changes. The results showed that in the group of naproxen microemulsion (60mg / kg) and high dose (120mg / kg) and the positive control group (aspirin enteric coated tablet, 100mg / kg) Compared with similar or stronger anti-inflammatory analgesic effect, and microemulsion can reduce the damage of naproxen on rat gastric mucosa.