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目的:研究核内不均一核糖核蛋白A2/B1(heterogeneous nuclear ribonucleoprotein A2/B1,hnRNP A2/B1)在正常子宫内膜、子宫内膜异位症(EMs)患者在位内膜、患者异位内膜间的表达差异。方法:用免疫组织化学法和Western blot分析,研究3例增生中晚期正常子宫内膜、3例增生中晚期EMs患者的在位内膜和异位内膜中,hnRNP A2/B1蛋白的表达差异。结果:hnRNP A2/B1主要表达于间质和腺上皮细胞的细胞核内,且EMs患者在位内膜和异位内膜中的表达强度,均低于正常内膜中的表达(P<0.05);而患者在位内膜和异位内膜中的表达,无明显差异(P>0.05)。结论:hnRNP A2/B1可能参与EMs的发生和发展。
Objective: To study the expression of hnRNP A2 / B1 and heterogeneous nuclear ribonucleoprotein A2 / B1 in eutopic and ectopic endometrium of patients with endometriosis and endometriosis (EMs) Endometrial expression differences. Methods: The expressions of hnRNP A2 / B1 protein in eutopic and ectopic endometrium of 3 patients with proliferative mid-late stage EMs were studied by immunohistochemistry and Western blot. . Results: The expression of hnRNP A2 / B1 in the nuclei of stromal and glandular epithelial cells was significantly lower than that in normal endometrium (P <0.05) There was no significant difference in endometriosis and ectopic endometrium (P> 0.05). Conclusion: hnRNP A2 / B1 may be involved in the occurrence and development of EMs.