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目的探讨新生儿双侧苍白球磁共振成像(MRI)信号强度与血清胆红素水平的关系,为胆红素脑病的诊断提供客观依据。方法对30例新生儿进行颅脑磁共振检查,并依血清总胆红素(Total Serum Bilirubin)水平分为正常范围、轻度增高、中度增高、重度增高4组。采用Philips Achieva 1.5T超导型磁共振扫描仪,对双侧苍白球T1加权成像(T1WI)信号强度、T2加权成像(T2WI)信号强度、弥散加权成像(DWI)指数表观弥散系数(EADC值)、弥散张力成像(DTI)表观弥散系数(ADC值)和部分各向异性(FA值)进行配伍组设计资料方差分析。结果血清总胆红素重度增高组双侧苍白球T1WI信号强度明显增高(P<0.05),且T1WI信号强度超过1155±63即为信号增高;T2WI信号强度、EADC(DWI)值、ADC(DTI)值、FA值4组差异无统计学意义(P≥0.05)。结论MRIT1WI双侧苍白球对称性高信号与高胆红素血症的严重程度密切相关,是新生儿胆红素脑病的重要特征。
Objective To investigate the relationship between magnetic resonance imaging (MRI) signal intensity and serum bilirubin level in neonatal bilateral globus pallidus and to provide an objective basis for the diagnosis of bilirubin encephalopathy. Methods Thirty newborns were examined by brain magnetic resonance imaging and divided into normal range according to the level of serum total bilirubin. They were slightly increased, moderately increased, and were significantly increased in 4 groups. The Philips Achieva 1.5T superconducting magnetic resonance scanner was used to measure the signal intensity of T1WI, the signal intensity of T2 weighted imaging (T2WI) and the apparent diffusion coefficient (EADC) of diffusion weighted imaging (DWI) ), Diffuse tension imaging (DTI) apparent diffusion coefficient (ADC value) and partial anisotropy (FA value). Results The signal intensity of T1WI in bilateral globus pallidus was significantly increased (P <0.05), and the signal intensity of T1WI exceeded 1155 ± 63. The signal intensity of T2WI, EADC (DWI), ADC ) Value, FA value of the four groups showed no significant difference (P≥0.05). Conclusion MRIT1WI bilateral globus pallidus symmetry of high signal and the severity of hyperbilirubinemia is closely related to neonatal bilirubin encephalopathy is an important feature.