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目的分析泰安地区不同年龄段支气管哮喘儿童过敏原特点,为环境控制和免疫治疗提供依据。方法应用免疫印迹法,对诊断为支气管哮喘儿童62例(≤3岁组26例;>3岁组36例)进行过敏原总IgE、特异性IgE浓度检测。结果总IgE检出率≤3岁组、>3岁组分别为19.23%、63.89%,两组差异有统计学意义(P<0.05)。1个以上过敏原检出率≤3岁组、>3岁组分别为76.92%(20/26)、88.9%(32/36),两组差异无统计学意义(P>0.05)。结论支气管哮喘儿童过敏原总IgE检出率随年龄增长有逐渐增长的趋势,吸入性过敏原是主要致敏因素以屋尘、尘螨为主。≤3岁屋尘是主要致敏因素,>3岁尘螨是主要致敏因素。
Objective To analyze the allergen characteristics of children with bronchial asthma in different age groups in Tai’an and provide the basis for environmental control and immunotherapy. Methods The total IgE and specific IgE levels of allergens were detected in 62 children with bronchial asthma (26 in ≤3 years and 36 in> 3 years old) by Western blotting. Results The detection rate of total IgE was less than 3 years old and> 3 years old respectively 19.23% and 63.89%. There was significant difference between the two groups (P <0.05). The detection rate of one or more allergens was 76.92% (20/26) and 88.9% (32/36) respectively in the groups of ≤3 years old and> 3 years old. There was no significant difference between the two groups (P> 0.05). Conclusion The detection rate of allergen total IgE in children with bronchial asthma tends to increase gradually with age. Allergenic allergens are the main allergens, mainly house dust and dust mites. ≤ 3 years old house dust is the main sensitizing factor,> 3 years old dust mite is the main sensitizing factor.