胃肠道间质瘤(GIST)是人类胃肠道最常见的间叶源性肿瘤,大多数GIST有原癌基因c-kit突变。近年的研究发现,在无c-kit突变的胃肠道间质瘤中,存在血小板源性生长因子受体-α(PDGFR-α)基因的突变。此外,尚存在很多基因和蛋白参与了GIST的发生和发展。与一般胃肠道肿瘤相比,GIST在组织发生、临床病理、诊断治疗、预后等方面有着不同的特点。本文主要综述有关GIST预后的相关指标的研究进展。 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human gastrointestinal tract. Most GISTs have proto-oncogene c-kit mutations. Recent studies have found that mutations in the platelet-derived growth factor receptor-α (PDGFR-α) gene exist in gastrointestinal stromal tumors without c-kit mutations. In addition, there are still many genes and proteins involved in the occurrence and development of GIST. Compared with general gastrointestinal tumors, GIST has different characteristics in tissue development, clinical pathology, diagnosis and treatment, and prognosis. This article summarizes the research progress on the related indicators of the prognosis of GIST.