目的:探讨氟西汀治疗伴有情绪障碍表现的肠易激综合征(IBS)患者的近期疗效,观察此类患者腹部症状与精神症状的相互关系。方法:40例伴有情绪障碍表现的肠易激综合征患者口服氟西汀8周,治疗前后分别对患者进行汉密尔顿抑郁量表(HAMD)和胃肠道症状计分标准(GSRS)的评估,观察疗效以及2种评分之间的相互关系。结果:有2例患者因出现不良反应退出研究,其余38例患者用药后的精神抑郁症状与腹部症状均有明显改善,治疗前后的HAMD和CSRS之间均存在显著差异(P<0.05)。而且HAMD与GSRS之间存在相关性(相关系数=0.65),表明肠易激综合征患者的腹部症状与情绪障碍之间存在一定相关性。结论:氟西汀对改善伴有情绪障碍的肠易激综合征患者的腹部症状及抑郁症状均有效果,提示抗抑郁治疗对此类患者有效。 Objective: To investigate the short-term efficacy of fluoxetine in the treatment of patients with irritable bowel syndrome (IBS) accompanied by emotional disorders and to observe the correlation between abdominal symptoms and mental symptoms in such patients. Methods: Forty patients with irritable bowel syndrome with mood disorders were treated with fluoxetine for 8 weeks. Before and after treatment, the Hamilton Depression Rating Scale (HAMD) and Gastrointestinal Symptom Score Scale (GSRS) were evaluated. To observe the efficacy and the relationship between the two scores. Results: Two patients withdraw from the study because of adverse reactions. The remaining 38 patients showed significant improvement in depression and abdominal symptoms after treatment. There was significant difference between HAMD and CSRS before and after treatment (P <0.05). There was also a correlation between HAMD and GSRS (correlation coefficient = 0.65), indicating that there was a correlation between abdominal symptoms and mood disorders in patients with irritable bowel syndrome. Conclusion: Fluoxetine is effective in improving the symptoms of abdominal and depressive symptoms in patients with irritable bowel syndrome accompanied by emotional disturbance, suggesting that antidepressant treatment is effective in these patients.