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目的探讨老年慢性肺心病患者血小板活化标志物PAC-1、CD62p的变化与高敏C反应蛋白(hs-CRP)的关系。方法用三色全血流式细胞术测定36例老年慢性肺心病患者外周血中血小板PAC-1、CD62p的表达水平,采用免疫比浊法测定hs-CRP,并与28例老年健康对照者及28例非老年健康对照者比较。结果老年慢性肺心病组PAC-1、CD62p、hs-CRP均明显高于老年健康对照组及非老年健康对照组(均P<0.001)。老年健康对照组PAC-1、CD62p阳性表达率亦高于非老年健康对照组(P<0.05)。老年慢性肺心病患者PAC-1、CD62的变化与hs-CRP呈正相关。结论老年慢性肺心病患者血小板明显活化,其活化程度与hs-CRP关系密切。
Objective To investigate the relationship between platelet activation markers PAC-1 and CD62p and high-sensitivity C-reactive protein (hs-CRP) in elderly patients with chronic cor pulmonale. Methods The levels of platelet PAC-1 and CD62p in peripheral blood of 36 elderly patients with chronic cor pulmonale were determined by tricolor whole blood flow cytometry. The hs-CRP was measured by immunoturbidimetry and was compared with 28 elderly healthy controls and 28 non-elderly healthy controls were compared. Results PAC-1, CD62p and hs-CRP in elderly patients with chronic cor pulmonale were significantly higher than those in healthy controls and non-elderly controls (all P <0.001). The positive expression rates of PAC-1 and CD62p in elderly healthy control group were also higher than those in non-elderly healthy control group (P <0.05). The changes of PAC-1 and CD62 in elderly patients with chronic cor pulmonale were positively correlated with hs-CRP. Conclusion Platelet activation is significantly activated in elderly patients with chronic cor pulmonale, and its activation is closely related to hs-CRP.