论文部分内容阅读
目的评价两地那非联合帕罗西汀治疗难治性早泄的临床疗效。方法评估指标：早泄指数(PE) 0～8分(没有=0分,几乎每次=8分),阴道内射精潜伏期评分(1VELT评分)0～3分(超过5min=0分,小于lmin=3分),并记录配偶性交满意频度(SSR)。本组共28例,口服帕罗西汀片剂20mg,每天1次,连续4周为1疗程,性交前2～3h口服两地那非50mg；疗程共3次(持续约4月余),全部病例完成用药并获随访。用药前及3月后分别评估病人早泄指数、IVELT评分,记录阴道内射精潜伏时间和配偶性交满意频度。结果治疗前早泄指数平均为5．69±0．13,IVELT评分为2．81±0．21,治疗后早泄指数平均为1．77±0．22,IVELT为0．16±0．36。治疗前后比较差异均有统计学意义(P＜0．01)。早泄改善者共26例,总有效率为92．86%,其中22例(78．26%)显效。不良反应未经特殊处理自动缓解。结论两地那非与帕罗西汀联合应用能明显改善难治性早泄患者的临床症状。
Objective To evaluate the clinical efficacy of the two non-paroxetine in the treatment of refractory premature ejaculation. Methods: The premature ejaculation index (PE) ranged from 0 to 8 (no score = 0, almost every score = 8), and the vaginal ejaculation latency score from 0 to 3 (more than 5 minutes = 0 minutes, less than 1 minute = 3 points), and record spouse sexual satisfaction frequency (SSR). The group of 28 cases, oral paroxetine tablets 20mg, 1 day, for 4 weeks for a course of treatment, 2 ~ 3h before oral delivery of two non-50mg; treatment of a total of 3 times (lasting about 4 months), all cases Complete the medication and be followed up. Before treatment and after 3 months, respectively, the patient’s premature ejaculation index, IVELT score, record the vaginal ejaculation latency and spouse sexual intercourse satisfaction frequency. Results Before treatment, the mean premature ejaculation index was 5.69 ± 0.13, the IVELT score was 2.81 ± 0.21. The mean premature ejaculation index was 1.77 ± 0.22 and IVELT was 0.16 ± 0.36 after treatment. Before and after treatment, the differences were statistically significant (P <0.01). Premature ejaculation improved in a total of 26 cases, the total effective rate was 92.86%, of which 22 cases (78.26%) markedly effective. Adverse reactions automatically relieved without special treatment. Conclusions The combination of fenavin and paroxetine can significantly improve the clinical symptoms of patients with refractory premature ejaculation.