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目的探讨孕中期产前筛查的临床应用价值。方法测定11 909例孕中期孕妇血清标志物甲胎蛋白(AFP)和人绒毛膜促性腺激素(β-HCG)值,采用Auto DELFIA 1235全自动免疫分析系统得出唐氏综合征、18-三体综合征、神经管缺陷(NTD)三种疾病的风险值,高风险者采用胎儿羊水染色体核型分析以及三维B超进行确诊。结果筛查的11 909例孕妇中,高风险孕妇1976例,阳性率为16.59%,经染色体检查或三维B超诊断,确诊唐氏综合征9例,18-三体综合征3例,NTD 0例,其他缺陷异常10例。结论对孕中期孕妇进行产前筛查是减少染色体疾病和神经管缺陷患儿出生的有效方法。
Objective To explore the clinical value of prenatal screening during the second trimester of pregnancy. Methods AFP and human chorionic gonadotropin (β-HCG) were detected in 11,909 pregnant women of the second trimester. The serum samples of Down syndrome and 18-trimesin were obtained by Auto DELFIA 1235 automatic immunoassay system. Body syndrome, neural tube defects (NTD) three risk values, high risk of fetal amniotic fluid karyotype analysis and three-dimensional B-ultrasound diagnosis. Results Of 11 909 pregnant women who were screened, there were 1976 high-risk pregnant women with a positive rate of 16.59%. Nine patients with Down’s syndrome, 3 with 18-trisomy syndrome and NTD 0 were confirmed by chromosomal examination or three-dimensional B- Cases, other defects in 10 cases. Conclusion Prenatal screening of pregnant women during the second trimester is an effective method to reduce the birth of children with chromosomal diseases and neural tube defects.