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目的:计数卵巢上皮性肿瘤中微血管密度及微淋巴管密度,探讨其与临床病理因素间的关系,及对患者预后的影响。方法:采用免疫组织化学方法检测10例正常卵巢上皮,48例良性卵巢上皮性肿瘤,47例交界性卵巢上皮性肿瘤以及205例恶性卵巢上皮性肿瘤组织中CD34及D2-40的表达。结果:正常卵巢组织中的MVD、LMVD值较良性、交界性及恶性卵巢上皮性肿瘤组织中的值显著降低,差异均有统计学意义(P均<0.05)。恶性上皮性卵巢肿瘤组织中MVD、LMVD值与肿瘤的临床分期、分化程度、有无淋巴结转移有关,差异有统计学意义(P均<0.05),但与患者的年龄无关(P>0.05)。多血管组及多淋巴管组的患者术后平均生存时间较少血管组及少淋巴管组显著降低,差异有统计学意义(P均<0.05),两者的表达水平均与患者术后生存时间呈负相关(P<0.05)。结论:随着卵巢上皮性肿瘤恶性程度的增加,MVD及LMVD值升高,与肿瘤的低分化、高分期、淋巴结转移有关,预示患者预后不良。
OBJECTIVE: To count the microvessel density and lymphatic vessel density in ovarian epithelial neoplasm, and to explore its relationship with clinicopathological factors and prognosis. Methods: Immunohistochemical method was used to detect the expression of CD34 and D2-40 in 10 cases of normal ovarian epithelium, 48 cases of benign ovarian epithelial tumor, 47 cases of borderline ovarian epithelial tumor and 205 cases of malignant ovarian epithelial tumor. Results: The values of MVD and LMVD in normal ovarian tissues were significantly lower than those in benign, borderline and malignant ovarian epithelial tumors (P <0.05). MVD and LMVD in malignant epithelial ovarian tumor correlated with clinical stage, differentiation and lymph node metastasis (P <0.05), but not with age (P> 0.05). The mean survival time of patients in multi-vessel group and multi-vessel group was significantly lower than that in vessel group and the lymphatic vessel group (all P <0.05), both of which were correlated with postoperative survival Time was negatively correlated (P <0.05). Conclusion: With the increase of the malignant degree of ovarian epithelial tumor, the MVD and LMVD values increase, which are related to the poorly differentiated tumor, high staging and lymph node metastasis, which indicates the poor prognosis.