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血小板粘附于受损伤的血管是止血过程中最先发生的止血反应，在血栓形成中也可能存在这种机理[1]。近年研究发现，内皮细胞合成释放的一种具有强烈缩血管作用的内皮素（ET），通过影响血管功能状态来参与心、脑、肺及肾脏疾病的发生发展。可作为内皮细胞受损的分子标志物[2]。
Platelet adhesion to damaged blood vessels is the first hemostatic reaction in the process of hemostasis, which may also occur in thrombosis [1]. In recent years, it has been found that endothelin, a vasoconstrictue-releasing endothelin, released by endothelial cells participates in the development of heart, brain, lung and kidney diseases by affecting the function of blood vessels. Can be used as a molecular marker of endothelial cell damage [2].