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目的掌握10岁以下儿童麻疹抗体水平,为麻疹防控提供科学依据。方法用分层抽样方法随机抽取488名6个年龄组的婴幼儿,采用酶联免疫吸附试验(ELISA)检测麻疹IgG抗体,结合免疫史对不同人群麻疹抗体进行分析。结果 10岁以下儿童麻疹IgG阳性率为84.51%,抗体几何平均滴度(GMT)为1∶708;6岁组和18月龄组阳性率最高,分别达到90.48%和89.47%,<8月龄组阳性率最低,为56.34%,GMT较高的是18月龄组,为1∶978,较低的是<8月龄组,为1∶370,接种第1剂麻疹IgG抗体阳性率为76.42%,GMT为1∶484,接种第2剂麻疹IgG抗体阳性率达到88.12%,GMT达到1∶839,男性与女性麻疹IgG抗体水平无差异。结论 <8月龄婴幼儿麻疹抗体水平偏低,是目前防治麻疹的关键群体,8月龄至10岁儿童具有较好的免疫屏障。应加强血清学监测,根据监测结果适时开展强化免疫。
Objective To grasp the level of measles antibody in children under 10 years of age and provide a scientific basis for prevention and control of measles. Methods 488 infants and young children of 6 age groups were randomly selected by stratified sampling method. The measles IgG antibodies were detected by enzyme - linked immunosorbent assay (ELISA), and the antibody against measles in different population was analyzed with the immunization history. Results The positive rate of measles IgG was 84.51% and the geometric mean antibody titer (GMT) was 1:708 for children under 10 years of age. The positive rates were 90.48% and 89.47% in 6-year-old group and 18-month old group, respectively. The lowest positive rate was 56.34%. The higher GMT was 18 months old, which was 1: 978, the lower was <8 months old, which was 1: 370. The positive rate of the first immunization with measles IgG was 76.42 %, The GMT was 1:484, the positive rate of measles IgG antibody in the second dose was 88.12%, and the GMT was 1:839. There was no difference in the level of measles IgG between male and female. Conclusion The level of measles antibody in infants aged <8 months is low, which is the key group to control measles at present. Children aged from 8 months to 10 years have good immune barrier. Serological surveillance should be strengthened, according to the monitoring results in a timely manner to strengthen the immune.