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采用Ａｍｅｓ试验，小鼠骨髓多染红细胞（ＰＣＥ）微核试验，中国仓鼠肺细胞（ＣＨＬ）染色体畸变试验，人外周血淋巴细胞染色体畸变试验和姐妹染色单体互换（ＳＣＥ）试验对利凡诺进行检测。结果利凡诺在ＴＡ９７、ＴＡ１００和ＴＡ１０２菌株±Ｓ９ｍｉｘ时剂量１～１００μｇ／皿阴性，ＴＡ９８菌株－Ｓ９阴性，＋Ｓ９阳性，显示出诱变性。各剂量组微核细胞率０．９‰～１．２‰，与溶剂对照１．０％比较，无显著差异（Ｐ＞０．０５），３个剂量组ＣＨＬ细胞染色体畸变率在正常范围（＜５％）。不同时相人外周血淋巴细胞染色畸变率和ＳＣＥ频率分别与对照比较，无显著差异（Ｐ＞０．０５）。研究结果表明利凡诺无诱发小鼠骨髓ＰＣＥ微核、ＣＨＬ细胞染色体畸变、人外周血淋巴细胞染色体畸变和ＳＣＥ频率的增加作用。仅发现利凡诺对ＴＡ９８菌株（＋Ｓ９ｍｉｘ）有诱发回复突变菌落数增加作用，是一种细菌致突变剂，但对人体不产生潜在遣传危害。
Ames test, mouse bone marrow polychromatic erythrocyte (PCE) micronucleus test, Chinese hamster lung cell (CHL) chromosome aberration test, human peripheral blood lymphocyte chromosome aberration test and sister chromatid exchange (SCE) Connaught for testing. Results Rivaroxel had a dose of 1 ~ 100μg / dish negative in TA97, TA100 and TA102 strains ± S9mix, TA98 strain-S9 negative and + S9 positive, showing mutagenicity. There was no significant difference between the two groups (P> 0.05). The chromosome aberration rate of CHL cells in three dose groups was within the normal range ( <5%). There was no significant difference (P> 0.05) between the staining aberration rate and SCE frequency of peripheral blood lymphocytes in different time phases compared with the control. The results show that rivanol induced PCE micronuclei in mice bone marrow, CHL cell chromosome aberrations, human peripheral blood lymphocyte chromosome aberrations and SCE frequency increased. Only found rivanol on TA98 strains (+ S9mix) have induced the number of colonies back to restore the effect of mutation, is a bacterial mutagen, but does not produce potential harm to the human body.