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为了解婴儿按 0、1、6个月程序接种 3剂乙型肝炎 (乙肝 )疫苗后 ,对抗体应答低下者实施再免疫后的乙肝病毒表面抗体 (抗 -HBs)阳转状况 ,在正定县 7个乡选取 1997年 1月 1日～ 1998年 8月 31日出生的婴儿 ,按 0、1、6个月程序实施 3剂乙肝疫苗免疫 ,于 1999年 5月采血检测抗 -HBs、乙肝病毒表面抗原 (HBsAg)和乙肝病毒核心抗体 (抗 -HBc) ,对 3项指标均阴性的 90例又接种了 1～ 2剂乙肝疫苗 ,2剂间隔 1个月 ,分别在每剂接种 1个月后采血检测抗 -HBs。结果显示 :再免疫 1剂乙肝疫苗后 1个月抗 -HBs阳转率为 85 6 % (S/N≥ 2 1)和 6 5 6 % (S/N≥10 0 )。对再免疫 1剂后仍无抗体应答者中的 8例又接种了第 2剂乙肝疫苗 ,经 1个月检测抗 -HBs全部阳转 ,其中 4例抗体S/N值≥ 10 0 ;同时对再免疫 1剂后抗 -HBs弱阳性 (S/N值 2 1～ 9 9)者中的 15例又接种了第 2剂乙肝疫苗 ,经 1个月后检测仅 4例抗 -HBsS/N值≥ 10 0 ,占 2 6 7%。因此 ,对按 3剂标准程序接种乙肝疫苗后免疫失败者再接种疫苗 ,可以诱导抗 -HBs阳转。
In order to understand the baby 0,1,6 months according to the program of three doses of hepatitis B (hepatitis B) vaccine, antibody response is low after the re-immunization of hepatitis B virus surface antigen (anti-HBs) positive condition, Zhengding County Seven townships selected infants born from January 1, 1997 to August 31, 1998, and administered three doses of hepatitis B vaccine according to the 0,1,6-month program. In May 1999, blood samples were collected for detection of anti-HBs and hepatitis B virus surface Antigen (HBsAg) and hepatitis B virus core antibody (anti-HBc) were administered to 1 to 2 hepatitis B vaccines against 90 patients who were negative for all three indicators. Blood test anti-HBs. The results showed that anti-HBs positive rate was 85.6% (S / N≥2 1) and 656% (S / N≥10 0) at one month after re-immunization of one dose of hepatitis B vaccine. Of the 8 patients who did not have any antibody response after re-immunization, 8 patients were inoculated with the second dose of hepatitis B vaccine. After 1 month, all the anti-HBs positive were detected, of which 4 patients had S / N ≥10 0; After re-immunization of one dose of anti-HBs weak positive (S / N value of 2 1 ~ 9 9) of 15 patients were inoculated with the second dose of hepatitis B vaccine, tested after 4 months only 1 anti-HBsS / N value ≥ 10 0, accounting for 26.7%. Therefore, three doses of standard hepatitis B vaccine immunization after vaccination and then vaccination, can induce anti-HBs positive.