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目的探讨多学科技术联合125Ⅰ治疗恶性梗阻性黄疸的疗效及不良反应。方法18例癌性梗阻性黄疸,A组9例,采用经食管逆行胆管引流(ERBD)术后CT引导下植入125Ⅰ粒子,B组9例,术中植入125Ⅰ后行胆肠吻合术,2个月后观察经两个方案治疗后缓解率并复查肝功能。结果A组肿瘤缓解率为44%,B组肿瘤缓解率为56%,两组肿瘤缓解率差异无统计学意义(P>0.05),肝功能恢复也无明显差异(P>0.05)。结论多学科技术联合125Ⅰ治疗癌梗阻性黄疸有较好疗效,术中与CT引导下植入对于肿瘤缓解率、肝功能恢复无明显差异,CT引导下植入患者术后恢复较快。
Objective To investigate the efficacy and adverse reactions of multidisciplinary technique combined with 125 Ⅰ in the treatment of malignant obstructive jaundice. Methods 18 cases of malignant obstructive jaundice, 9 cases in group A, 125 Ⅰ seeds were implanted under CT guided by esophageal retrograde biliary duct drainage (ERBD), 9 cases in group B, and choledochojejunostomy was implanted 125 days after operation. Two months later, the rates of remission after two regimens were observed and liver function was examined. Results The remission rate was 44% in group A and 56% in group B. There was no significant difference in remission rate between two groups (P> 0.05). There was no significant difference in the recovery of liver function (P> 0.05). Conclusions Multidisciplinary technique combined with 125 Ⅰ has a good curative effect in treating patients with obstructive jaundice. There is no significant difference in the rate of tumor remission and the recovery of liver function between operation and CT guided implantation. The patients under CT guidance recover quickly.