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1960-1985年共收治5050例鼻咽癌患者,年龄小于20岁114例(2.26％),其中99例已随访满5年,14岁以下(儿童组)8例,15-20岁(青少年组)91例。儿童组青少年组及二组总的5年生存率分别为25％、46.2％和44.4％。儿童组、青少年组5年生存率在统计学上无显著差异,二组总的5年生存率与成年组5年生存率间无显著差异(P>0.05)。影响儿童及青少年患者预后的主要因素是临床分期,症状出现到就诊时间、颈部淋巴结情况,及原发灶大小。儿童及青少年患者放疗后可能引起垂体功能低下的后遗症,要控制野的大小和肿瘤剂量。
From 1960 to 1985, a total of 5,050 patients with nasopharyngeal carcinoma were treated. Of the 114 patients (2.26%) who were younger than 20 years of age, 99 had been followed up for 5 years. Children under 14 years of age (children group) were 8 and 15-20 years old (adolescent group ) 91 cases. The total 5-year survival rates of the juvenile group and the second group in the children group were 25%, 46.2%, and 44.4%, respectively. There was no statistically significant difference in the 5-year survival rate between the children group and the adolescent group. There was no significant difference between the total 5-year survival rate of the two groups and the 5-year survival rate of the adult group (P>0.05). The main factors affecting the prognosis of children and adolescents are clinical stage, symptom onset, time to visit, cervical lymph node status, and size of the primary lesion. After radiotherapy in children and adolescents, it may cause sequelae of hypopituitarism, and it is necessary to control the size of the field and the tumor dose.