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目的研究不同剂量阿托伐他汀对急诊PCI术后患者炎症因子水平的影响。方法入选100例急性心肌梗死患者随机分为A组阿托伐他汀20mg/d,B组阿托伐他汀40mg/d,C组阿托伐他汀80mg/d,测治疗前后血清C反应蛋白、白介素6及血脂肝功能肌酸激酶。结果应用阿托伐他丁治疗各组CRP、IL-6、TCH、TG、LDL-C水平显著降低,80mg治疗组更为显著,无1例出现肝功损害和出现过敏肌痛等现象。结论阿托伐他汀能降低急诊PCI术后患者炎症因子水平,且呈剂量依赖性。
Objective To study the effects of different doses of atorvastatin on the levels of inflammatory cytokines in patients after emergency PCI. Methods One hundred patients with acute myocardial infarction were randomly divided into two groups: atorvastatin 20 mg / d in group A, atorvastatin 40 mg / d in group B and atorvastatin 80 mg / d in group C, serum C - reactive protein, interleukin 6 and blood fat liver function creatine kinase. Results The levels of CRP, IL-6, TCH, TG and LDL-C in atorvastatin group were significantly decreased after treatment with atorvastatin, and were more significant in the 80 mg treatment group. None of the patients had liver damage or hyperalgesia. Conclusions Atorvastatin can reduce the level of inflammatory cytokines in emergency patients after PCI and in a dose-dependent manner.