吸烟是慢性阻塞性肺病的主要致病因素,吸烟的数量、种类和方式均影响慢性阻塞性肺病的发生。吸烟可引起炎症细胞、细胞因子发生变化,导致气道损伤;吸烟是否发生慢性阻塞性肺病还与人群的易感性有关,如与α_1-抗胰蛋白酶、Vito胶联蛋白、家族遗传倾向等均有关。 Smoking is the main risk factor of COPD. The quantity, types and ways of smoking affect the occurrence of chronic obstructive pulmonary disease. Smoking can cause changes in inflammatory cells and cytokines, leading to airway injury; whether smoking occurs in chronic obstructive pulmonary disease is also associated with the susceptibility of the population, such as α_1-antitrypsin, Vito collagen, family genetic predisposition and so on .